A new bat coronavirus, HKU5-CoV-2, discovered in China, shows potential for human infection through ACE2 binding similar to SARS-CoV-2. Led by renowned virologist Shi Zhengli, the study raises concerns about possible zoonotic transmission. Experts suggest that existing immunity may lessen pandemic risks, as the virus demonstrates lower binding affinity to human receptors than its predecessors.

Researchers in China have identified a new bat coronavirus named HKU5-CoV-2, which has the potential for animal-to-human transmission, akin to the virus responsible for the COVID-19 pandemic. Led by the prominent virologist Shi Zhengli, the study was reported by the South China Morning Post. HKU5-CoV-2 has been discovered to bind to ACE2 receptors in humans, allowing it to infiltrate human cells similar to SARS CoV-2, the virus that caused COVID-19.

Belonging to the merbecovirus subgenus, HKU5-CoV-2 is genetically related to the MERS virus. Laboratory tests indicated that the new coronavirus can infect human cell cultures, revealing its ability to utilize human ACE2 for entry. While the research points to a significant risk of spillover into humans, the authors noted that further investigation is needed to assess this risk.

Scientists concluded that HKU5-CoV-2 exhibits a better adaptation capability to human ACE2 compared to other related viruses. They highlighted the potential zoonotic risks posed by this virus lineage, indicating it can efficiently use human receptors. However, it remains uncertain whether this virus can cause disease in humans.

In response to concerns regarding another potential pandemic, Dr. Michael Osterholm from the University of Minnesota assessed the reactions to the study as exaggerated. He emphasized that existing immunity in the population to similar SARS viruses could mitigate the risk. Importantly, the study emphasized that HKU5-CoV-2 has a lower binding affinity to human ACE2 than SARS-CoV-2, suggesting a reduced likelihood of it emerging in human populations.

In conclusion, the discovery of HKU5-CoV-2 raises important questions about zoonotic diseases and potential transmission to humans. While preliminary findings indicate a similarity to SARS-CoV-2, experts advise caution in interpreting its implications for public health. Continued research is essential to monitor its status and to enhance our understanding of coronaviruses and their potential risks.

Original Source: www.ndtv.com

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